EFFECTS OF CONCENTRATED AMBIENT PARTICLES ON HEART RATE, BLOOD PRESSURE, AND CARDIAC CONTRACTILITY IN SPONTANEOUSLY HYPERTENSIVE RATS DURING A DUST STORM EVENT
Resource
INHALATION TOXICOLOGY v.19 n.11 pp.973-978
Journal
INHALATION TOXICOLOGY
Journal Volume
v.19
Journal Issue
n.11
Pages
973-978
Date Issued
2007
Date
2007
Author(s)
CHANG, CHUN-CHAO
HWANG, JING-SHIANG
CHAN, CHANG-CHUAN
Abstract
Epidemiological studies have suggested that cardiovascular
mortality and morbidity increased during Asian dust events.
The findings were still inconclusive though. We have shown
an increased pulmonary toxicity in diseased animals during a
dust storm event. However, the toxicity nature of dust
storm particles remains unclear. It is our objective in this
study to further investigate the cardiovascular effects of
concentrated PM2.5 on spontaneously hypertensive rats during
the same dust storm event. Four spontaneously hypertensive
rats were implanted with radiotelemetry transmitters at the
age of 10 wk. Baseline heart rate, mean blood pressure, and
cardiac contractility (measured as QA interval, QAI) data
were collected 4 wk before. Exposure group received
concentrated ambient particles inhalation for 6 h during a
dust storm event, while the control group received room air
inhalation at the same time. Self-control data were
collected 4 wk after the event during the same clock hours
while there was no dust storm. Gravimetric analysis showed a
particle mass concentration of 315.55 mu g/m(3) during the
6 h of exposure. A linear mixed-effects model revealed
sigmoid increases in heart rate (to a maximum of 93.8 +/- 18
.8 bpm) and mean blood pressure (to a maximum of 14.8 +/- 5.
4 mm Hg), and a sigmoid decrease of QAI (to a maximum of -3
. 5 +/- 1.5 ms) during the exposure after an initial
incubation period. We conclude that concentrated dust storm
particles, which are different from products of automobile
combustion process, may cause adverse cardiovascular effects
on diseased animals.
Subjects
OIL FLY-ASH
PARTICULATE AIR-POLLUTION
CARDIOVASCULAR-DISEASE
DAILY MORTALITY
TAIWAN
PULMONARY
SDGs
Type
journal article