The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion
Journal
Pharmaceutical research
Journal Volume
40
Journal Issue
11
Pages
2541
Date Issued
2023-11
Author(s)
Chiang, Hui-Ling
Wu, Kuo-Chen
Chen, You-Yin
Ho, Chin-Jui
Wang, Han-Lin
Fu, Yu-Hua
Chen, Wen-Yu
Abstract
Cerebral vascular protection is critical for stroke treatment. Adenosine modulates vascular flow and exhibits neuroprotective effects, in which brain extracellular concentration of adenosine is dramatically increased during ischemic events and ischemia-reperfusion. Since the equilibrative nucleoside transporter-2 (Ent2) is important in regulating brain adenosine homeostasis, the present study aimed to investigate the role of Ent2 in mice with cerebral ischemia-reperfusion.
Subjects
adenosine; blood-brain barrier; equilibrative nucleoside transporters; ischemia-reperfusion injury; neuroinflammation
SDGs
Type
journal article