Association of Placenta Growth Factor and Vascular Endothelial Growth Factor with Angiogenesis and Clinical Outcome in Human Gastr ic Cancer
Date Issued
2002
Date
2002
Author(s)
Chen, Chiung-Nien
DOI
902314B002339
Abstract
Angiogenesis is a very complex phenomenon and essential for the growth of solid
tumors measuring more than a few millimeters. It permits rapid tumor growth and
potential presence of tumor metastasis. Tumor angiogenesisis is a significant predictor
of prognosis and hematogenous metastasis of patients with gastric cancer.
Angiogenesis is not a passive process and is driven by many angiogenic factors
produced by tumor. Of the known angiogenic factors, vascular endothelial growth
factor (VEGF) have been shown to play an important role not only in angiogenesis
and prognosis of different human tumors, but also in physiological and nonmalignant
pathological conditions.
Placenta growth factor (PlGF) is a member of the VEGF family of proangiogenic
factors. VEGF binds with high affinity to two tyrosine kinase receptors: VEGF
receptor-1 (Flt-1) and VEGFR-2 (Flk-1). PlGF binds with high affinity to Flt-1 but
not to Flk-1. In contrast to VEGF, PlGF is not regulated by hypoxia and its
physiological roles are largely unknown. PlGF is upregulated in placenta and during
the active angiogenic phase of wound healing. Its upregulation has been found in
human meningiomas, hemangioblastomas, melanoma, cervical squamous cell
carcinoma and associated with angiogenesis in renal cell carcinoma. However, PlGF
was down regulated in thyroid carcinoma, germ cell tumor, and cervical
adenocarcinoma. To our knowledge, there has been no report on PlGF expression of
human gastric cancer and its correlation with clinical outcome.
Therefore, we quantitated expression of VEGF and PlGF in human gastric cancer
tissues, which represent an important mechanism of angiogenesis, by enzyme
immunoassays and compared with microvessel density and other clinicopathological
variables as a basis for rational future therapeutic antiangiogenic approaches to gastric
cancer treatment.
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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