The mRNA profile of genes in betel quid chewing oral cancer patients
Journal
Oral Oncology
Journal Volume
40
Journal Issue
4
Pages
418-426
Date Issued
2004
Author(s)
Abstract
Oral cancer is one of the most common types of human cancer in the world. Although the risk factors for oral cancer are well-recognized in different countries, the molecular mechanism responsible for this malignancy remains elusive particularly in the countries where betel quid chewing is prevalent. The cDNA microarray analysis was used to analyse the mRNA expression patterns of 1177 genes in ten oral cancer patients with betel quid chewing history. Eighty-four genes involving cell adhesion, cell shape, growth, apoptosis, angiogenesis, metastasis, and metabolism were deregulated. Although the expression profile of these genes was shared by certain clinical patients, there was no significant association of the expression profile with clinical staging. Functional implication of four validated genes including caspase-1, STAT-1, COX-2 and pleiotrophin was discussed. This study provides pilot data for understanding the pathogenesis of oral cancer in countries like Taiwan where betel quid chewing is prevalent. ? 2003 Elsevier Ltd. All rights reserved.
Subjects
Betel quid; cDNA; Gene profile; Microarray; Oral cancer; Squamous cell carcinoma
Other Subjects
complementary DNA; cyclooxygenase 2; interleukin 1beta converting enzyme; messenger RNA; pleiotrophin; STAT1 protein; adult; anamnesis; angiogenesis; apoptosis; article; betel nut; cancer patient; cancer staging; cell adhesion; cell growth; cell shape; clinical article; controlled study; deregulation; disease association; DNA microarray; gene; gene expression; human; male; mastication; metabolism; metastasis; mouth cancer; priority journal; RNA analysis
Publisher
Elsevier Ltd
Type
journal article