The Effect of Single or Combination Formulas Comprising of Onion, Lemon and Drynaria fortunei J. Sm on Osteoporosis. A Menopausal Ovariectomized Mice Model.
Date Issued
2015
Date
2015
Author(s)
Lin, Po-Yu
Abstract
Osteoporosis (OP) is the most prevalent skeletal disorder characterized by decreased bone mass and bone mineral density, which leads to impaired skeletal strength and increased susceptibility to fractures. This experiment established the ovariectomized (OVX) mouse model of postmenopausal osteoporosis, and examined the effect of supplementation with drinks and foods containing single and combination formulas comprising onion, lemon and Drynaria fortunei J. Sm. on ad libitum food intake and on bone mineral density (BMD). Two weeks after osteoporosis had been induced and 8 weeks after feeding had begun the tibia BMD of OVX mice administered (a) onion 0.7g, (b) lemon 0.7g, (c) Drynaria fortune 0.7g, and (d) onion 0.25g/lemon 0.25g/Drynaria fortune 0.25g showed significant increases compared with that of all other groups of OVX mice. Closer examination using microcomputed tomography (micro-CT) also revealed that the (a)(b)(c)(d)-administered mice had denser trabecular bone volume/tissue volume (BV/TV) and a higher trabecular number (Tb.N)、Trabecular thickness(Tb.Th)、BMD values compared to all other mouse groups, whereas trabecular separation (Tb.Sp) was significantly lower in the OVX group. As for the serum calcium and phosphorus, the values showed no significant differences among all groups in our experiment. These findings indicate that administration of single and combination formulas comprising onion, lemon and Drynaria fortunei could retard bone loss induced by estrogen deficiency and reduce the risk of osteoporosis.
Subjects
Osteoporosis
Onion
Lemon
Drynaria fortunei J. Sm.
Microcomputed tomography
Type
thesis
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