Sensory functions beyond taste: multifaceted role of solitary chemosensory cells and taste receptors in mucosal immune defense and disease pathogenesis.
Journal
Life sciences
Journal Volume
391
Start Page
124280
ISSN
1879-0631
Date Issued
2026-04-15
Author(s)
Abstract
Taste receptors are most commonly associated with the experience of flavor. However, these receptors are also crucial participants in wider physiological mechanisms, particularly immunological defense. Solitary chemosensory cells (SCCs) express taste receptors (e.g., TAS2Rs and TAS1Rs) and are distributed throughout many organs, including the oral cavity, respiratory system and gastrointestinal tract. These cells function as sensors for dangerous bacteria and trigger immunological responses to preserve the integrity of mucosal tissues and prevent disease. Recent research has revealed that SCCs also play crucial roles in the development of many medical conditions, including dental caries, periodontitis, chronic rhinosinusitis, inflammatory bowel disease and cancer. This review details current knowledge on the distinct roles of SCCs in taste perception and pathogen sensing, highlighting the potential of these cells as targets for therapeutic interventions. Intriguingly, recent evidence suggests that it may be possible to target taste receptor pathways for treating a wide range of health concerns. To fully understand the therapeutic potential of taste receptors, future work will be needed to delineate the associated molecular and physiological pathways in contexts beyond the mouth. Expanding our knowledge of SCCs and taste receptors may provide insights that lead to innovative approaches to prevent and treat diseases.
Subjects
Alimentary diseases
Mucosal immunology
Respiratory diseases
Solitary chemosensory cells
Taste receptors
Tuft cells
Type
journal article