Serum γ-glutamyl transpeptidase activity and bile acids in normal Taiwanese infants
Journal
Acta Paediatrica Taiwanica
Journal Volume
43
Journal Issue
5
Pages
245-248
Date Issued
2002
Author(s)
Abstract
To facilitate making a diagnosis of cholestatic liver disease in Taiwan, we have established reference ranges for serum γ-glutamyl transpeptidase (γ-GT) activity and bile acids in normal Taiwanese infants. The serum level of γ-GT activity was assayed in 90 normal Taiwanese infants and children aged between 2 days and 2 years old. These data were analyzed in twenty-three 0-3-month-old, twenty-four 4-6-month-old, and forty-three 7-24-month-old infants. The mean values of serum γ-GT activity were 47.4±26.6, 21.5±7.3, and 14.0±3.2 1U/L for the respective age groups. The highest reference γ-GT values were 99.5, 35.8, and 20.3 1U/L for the respective age groups. The mean values of serum γ-GT activity were highest in infants younger than 3 months, and these gradually decreased to the adult level with age (p < 0.01). Serum bile acids were measured in 24 premature and 56 full-term infants. The mean values of serum bile acids were 34.5±34.5 μmol/L in preterm infants and 18.7±21.9 μmol/L in full-term babies. The bile acid levels of preterm infants were higher than those in full-term babies (p < 0.01).
SDGs
Other Subjects
bile acid; gamma glutamyltransferase; article; bile acid blood level; differential diagnosis; enzyme activity; gamma glutamyl transferase blood level; human; infant; intrahepatic cholestasis; newborn; normal human; prematurity; Taiwan; Bile Acids and Salts; gamma-Glutamyltransferase; Humans; Infant, Newborn; Reference Values; Taiwan
Type
journal article