Molecular and cytoskeletal regulations in epidermal development
Journal
Seminars in Cell and Developmental Biology
Journal Volume
69
Pages
18-25
Date Issued
2017
Author(s)
Abstract
At the surface of the body, the epidermis covers great depth in its developmental regulation. While many genes have been shown to be important for skin development through their associations with disease phenotypes in mice and human, it is in the past decade that the intricate interplay between various molecules become gradually revealed through sophisticated genetic models and imaging analyses. In particular, there is increasing evidence suggesting that cytoskeleton-associated proteins, including adhesion proteins and the crosslinker proteins may play critical roles in regulating epidermis development. We here provide a broad overview of the various molecules involved in epidermal development with special emphasis on the cytoskeletal components. © 2017 Elsevier Ltd
Subjects
Cell junction; Cytoskeleton; Molecular mechanism; Skin development; Spectraplakin
SDGs
Other Subjects
adherens junction protein; bullous pemphigoid antigen 1; cytoskeleton protein; desmosome protein; membrane protein; mt and actin crosslinking factor 1 protein; spectraplakin; tight junction protein; unclassified drug; actin binding protein; cell adhesion molecule; adherens junction; basement membrane; cell differentiation; cytoskeleton; desmosome; epidermis; granular cell; human; keratinocyte; molecular biology; nonhuman; organogenesis; regulatory mechanism; Review; tight junction; animal; cytoskeleton; embryology; epidermis; metabolism; Animals; Cell Adhesion Molecules; Cytoskeleton; Epidermis; Humans; Microfilament Proteins
Type
review