Critical seed loading from nucleation kinetics
Journal
AIChE Journal
Journal Volume
60
Journal Issue
5
Pages
1645-1653
Date Issued
2014
Author(s)
Tseng Y.-T.
Abstract
A method is presented for preparing critical seed loading diagrams for nonaggregating systems knowing only the nucleation kinetics. This is advantageous because it is much less time-consuming than developing and solving a complete batch process model including solubility expressions and growth rate kinetics. Furthermore, there are many more reports available in the literature of nucleation kinetics alone than there are of complete batch crystallization process models, because expressions for the nucleation rate as a function of crystal growth rate can be rapidly determined from mixed-suspension, mixed-product-removal (MSMPR) data without measuring the supersaturation. The results for 43 systems show that there is a great deal of variability in the critical seed loading, and a single correlation is inadequate to describe the relationship between critical seed loading and seed size. For a seed size of 10 £g, seed loading can effectively suppress nucleation in 92% of cases, while for seeds of size 50, 100, and 200 £g, seed loading can suppress nucleation in 74, 61, and 39% of cases, respectively. ? 2014 American Institute of Chemical Engineers.
Subjects
Batch crystallization
Process design
Seed
Type
journal article