Electrocardiogram (ECG) abnormality and cardiovascular mortality among residents in arseniasis-endemic and non-endemic areas of southwestern Taiwan: A study of gene-gene and gene-environment interactions
Date Issued
2011
Date
2011
Author(s)
Liao, Ya-Tang
Abstract
Cardiovascular disease is a major cause of mortality worldwide, small increase in odds ratio may result in significant excess number of deaths. Arsenic is a potent but modifiable environmental pollutant that has been linked to increased prevalence of cardiovascular disease (CVD) and cancer globally. Arsenic-induced CVD may result from the inter-correlations among genetic, environmental factors though toxicological mechanisms. However much less was known about the excess mortality from arsenic with genetic factors considered. Although an association between chronic arsenic exposure and CVD has been found in many studies, nearly all of these studies were limited by use of cross-sectional data, and longitudinal evidence by follow-up study was still limited. Besides, majority of previous studies were focus on the clinical arsenic-related cardiovascular disease, instead of the manifest of preclinical or subclinical detections. Studies based on subclinical finding are needed to detect the early sign of chronic poisoning. The objective of this study is to investigate the joint contribution of genetic factors including PON1, AS3MT, and GSTO gene families and the long-term arsenic impacts on cardiovascular disease through measuring plasma LDH levels and ECG abnormality as subclinical phenotypes and to evaluate whether the arsenic methylation patterns modifies the association between cumulative arsenic exposure and the risk of CVD. Our studies demonstrated after cessation of arsenic-contaminated water consumption for decades, biomarkers for CVD mortality and morbidity was still associated with reduced risks for arsenic. Arsenic methylation profiles appeared to become more efficient among subjects after cessation of long-term exposure to high levels of arsenic. Besides, this study also illustrated significant gene-gene interaction and gene-environment on early effect markers for CVD. These results may have implications for arsenic mediation strategies in areas currently exposed to potentially harmful levels of arsenic in drinking water.
Subjects
Arsenic exposure
Ischemic heart disease
Electrocardiogram
Lactate dehydrogenase
Paraoxonase
Arsenic methyltransferase
Glutathione S-transferases omega
SDGs
Type
thesis
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