Effects of red mold fermented product to improve memory and learning ability on stroke rats
Date Issued
2014
Date
2014
Author(s)
Kuo, Jui
Abstract
Oxidative stress and apoptosis induced from cerebral stroke-reperfusion are involved in the cerebral stroke and reperfusion processes of impairment. In this research, every male Sprague-Dawley rats accept bilateral common carotid artery occlusion-reperfusion operation to induce memory and learning ability impairment of stroke. We examined the beneficial effects of the extract and secondary metabolite of red mold rice (RMR) in this model. The extract and secondary metabolite of RMR could improve cognitive impairment in behavior tests. We also found that extract and secondary metabolite of RMR reduce the expression of red mold rice glial fibrillary acidic protein (GFAP) which is elevated by stroke. Furthermore, the extract and secondary metabolite of RMR could reduce oxidative stress and apoptosis in rat’s brain. Effects of melatonin, as a contrast agent, was also examined in this research and show no significant improvement. This research shows that by suppressing lipid peroxidation and activating antioxidant enzyme, the extract and secondary metabolite of RMR could reduce oxidative stress and apoptosis and then ameliorates stroke pathology finally. Thus, protects rats against the impairment of memory and learning ability induced by stroke. In addition, these advantageous effects of the extract and secondary metabolite of RMR on stroke are even better than melatonin. This research proves that the extract and secondary metabolite of RMR could protect the brain from stroke and have multifunctional property in stroke treatment.
Subjects
中風
紅麴
再灌流
水迷宮
被動迴避
Type
thesis
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