Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus
Journal
Journal of the Formosan Medical Association
Journal Volume
117
Journal Issue
11
Pages
987-993
Date Issued
2018
Author(s)
Abstract
Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) have not yet been reported in recurrent aphthous stomatitis (RAS) patients with concomitant oral lichen planus (OLP/RAS patients). This study mainly assessed the frequencies of serum GPCA, TGA, and TMA (GPCA/TGA/TMA) positivities in 44 OLP/RAS patients. Methods: The frequencies of serum GPCA/TGA/TMA positivities in 44 OLP/RAS patients, OLP/RAS patients of four different subgroups, 520 RAS patients, and 352 healthy control subjects were calculated and compared. Results: We found that 20.5%, 27.3%, and 31.8% of 44 OLP/RAS patients, 75.0%, 100.0%, and 100.0% of 4 OLP/major-typed RAS (OLP/major RAS) patients, 15.0%, 20.0%, and 25.0% of 40 OLP/minor-typed RAS (OLP/minor RAS) patients, 45.5%, 72.7%, and 54.5% of 11 atrophic glossitis-positive OLP/RAS (AG+OLP/RAS) patients, and 12.1%, 12.1%, and 24.2% of 33 AG-negative OLP/RAS (AG?OLP/RAS) patients had the presence of GPCA, TGA, and TMA in their sera, respectively. OLP/RAS patients and OLP/RAS patients of four different subgroups all had significantly higher frequencies of GPCA/TGA/TMA positivities than healthy control subjects. Moreover, OLP/RAS patients had a significantly higher frequency of TMA positivity than RAS patients, and OLP/major RAS and AG+OLP/RAS patients had significantly higher frequencies of GPCA/TGA/TMA positivities than RAS patients. Furthermore, OLP/major RAS patients had significantly higher frequencies of GPCA/TGA/TMA positivities than OLP/minor RAS patients. Conclusion: For OLP/RAS patients, the concomitant OLP may play a role in causing an increased frequency of TMA positivity, and major RAS and the concomitant AG are contributory factors causing the elevated frequencies of GPCA/TGA/TMA positivities. ? 2018
SDGs
Other Subjects
microsome antibody; parietal cell antibody; thyroglobulin antibody; thyroid antibody; thyrotropin; anti-thyroglobulin; autoantibody; thyroid microsomal antibodies; adult; aged; antibody blood level; aphthous stomatitis; Article; clinical article; controlled study; female; glossitis; human; lichen planus; male; mouth ulcer; thyrotropin blood level; adolescent; aphthous stomatitis; blood; case control study; immunology; lichen planus; middle aged; stomach parietal cell; Taiwan; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Case-Control Studies; Female; Humans; Lichen Planus, Oral; Male; Middle Aged; Parietal Cells, Gastric; Stomatitis, Aphthous; Taiwan; Young Adult
Publisher
Elsevier B.V.
Type
journal article