Effects of anti-triadin antibody on Ca2+ release from sarcoplasmic reticulum
Journal
FEBS Letters
Journal Volume
299
Journal Issue
1
Pages
57-59
Date Issued
1992
Author(s)
JAW-JOU KANG
Abstract
The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel.
SDGs
Type
journal article