Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease
Journal
Neurology
Journal Volume
98
Journal Issue
8
Pages
E848
Date Issued
2022-02-22
Author(s)
Chen, Szu-Ju
Liao, Hsin-Yu
Lin, Ya-Ting
Wu, Yu-Wei
Abstract
Short-chain fatty acids (SCFAs) are gut microbial metabolites that promote the disease process in a rodent model of Parkinson disease (PD), but fecal levels of SCFAs in patients with PD are reduced. Simultaneous assessments of fecal and plasma SCFA levels, and their interrelationships with the PD disease process, are scarce. We aimed to compare fecal and plasma levels of different SCFA subtypes in patients with PD and healthy controls to delineate their interrelations and link to gut microbiota changes and clinical severity of PD.
Subjects
DIETARY HABITS; PATHOGENESIS; PROGRESSION; EXPRESSION; PATHWAYS; DEMENTIA; MODEL
SDGs
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Type
journal article