ACTH抗癲癇作用機制之探討(3/3)
Date Issued
2001
Date
2001
Author(s)
楊千立
DOI
892314B002491
Abstract
ACTH was demonstrated to affect
animal behavior. We also found that patients with
infantile spasm often become irritable when they
were receiving ACTH. Several evidences suggested
that amygdala may be a target for ACTH to affect
behavior and emotion. We studied the effect of
ACTH on ion channels of amygdala neurons in the
2nd year of this project, and studied the effect of
ACTH on synaptic plasticity, mainly LTD in
hippocampus in the 3rd year of the project. We
found that by acting through PKA, ACTH
augmented L type voltage gated calcium currents in
amygdala. But in hippocampus, ACTH inhibits
baseline synaptic response, but do not affect low
frequency stimuli-induced long term depression.
Subjects
adrenocorticotropic hormone
synaptic transmission
synaptic plasticity
ion channels
hippocampus
amygdala
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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