To evaluate the effect of oral chloral hydrate in different concentration combined with intramuscular injection Zoletil in Macaca cyclopis
Date Issued
2015
Date
2015
Author(s)
Chen, Chia-Li
Abstract
To make immobilizing and capturing wild Formosan Macaques more efficacy in practice, this study compared the different effects among using chloral hydrate alone, tiletamine-zolazepam alone and chloral hydrate – [tiletamine-zolazepam] combined in Formosan macaques. 11 female and 4 male macaques were collected. The 11 females were assigned randomly into A(n=3), B(n=4), and C(n=4) groups, and the 4 males were gathered in group D. Group A was given puff without drugs and injected tiletamine-zolazepam 2 mg/kg intramuscularly after 30 minutes. Group B was given puff with flavored Chloral Hydrate 100 mg/kg orally and injected sterile saline after 30 minutes. Group C and D were received flavored puff with Chloral hydrate 200 mg/kg orally and injected tiletamine-zolazepam 2 mg/kg intramuscularly after 30 minutes. During the procedures, the sedation level and anesthetic depth were recorded by using sedation index and scoring system for parameters of anesthetic depth. Data were analyzed by Least Signigicant Difference (LSD) of variance for significant (P<0.05). The result shows group C and group D provided significantly better sedation than group A and B, but no significance between group C and group D. This is the first study to discuss about oral chloral hydrate using for sedation and anesthesia with Zoletil in non-human primates. Hoping this study can apply in wild Formosan Macaques in the future and help alleviating the conflict of people and monkeys.
Subjects
Non-human primate
Macaca cyclopis
sedation
anesthesia
Type
thesis
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