Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis
Journal
The Lancet. Global Health
Journal Volume
10
Journal Issue
9
Pages
e1307
Date Issued
2022-09
Author(s)
Martinez, Leonardo
Cords, Olivia
Liu, Qiao
Acuna-Villaorduna, Carlos
Bonnet, Maryline
Fox, Greg J
Carvalho, Anna Cristina C
Chan, Pei-Chun
Croda, Julio
Hill, Philip C
Lopez-Varela, Elisa
Donkor, Simon
Fielding, Katherine
Graham, Stephen M
Espinal, Marcos A
Kampmann, Beate
Reingold, Arthur
Huerga, Helena
Villalba, Julian A
Grandjean, Louis
Sotgiu, Giovanni
Egere, Uzochukwu
Singh, Sarman
Zhu, Limei
Lienhardt, Christian
Denholm, Justin T
Seddon, James A
Whalen, Christopher C
García-Basteiro, Alberto L
Triasih, Rina
Chen, Cheng
Singh, Jitendra
Sharma, Surendra
Hannoun, Djohar
Del Corral, Helena
Mandalakas, Anna M
Malone, LaShaunda L
Ling, Du-Lin
Kritski, Afrânio
Stein, Catherine M
Vashishtha, Richa
Boulahbal, Fadila
Boom, W Henry
Netto, Eduardo Martins
Lemos, Antonio Carlos
Hesseling, Anneke C
Kay, Alexander
Jones-López, Edward C
Horsburgh, C Robert
Lange, Christoph
Andrews, Jason R
Abstract
BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate the age-specific impact of infant BCG vaccination on tuberculosis (pulmonary and extrapulmonary) development and mortality.
SDGs
Publisher
Elsevier Ltd
Type
journal article