Synthesis, characterization and drug release activity of poly(epichlorohydrin-g-furosemide) system
Journal
Chemical Papers
Journal Volume
72
Journal Issue
12
Pages
2987-2996
Date Issued
2018
Author(s)
Abstract
Abstract: The poly(epichlorohydrin) (PECH) was synthesized and structurally modified in the presence of furosemide (Fur) under nitrogen atmosphere at 50?¢XC for 4?h and characterized by various analytical techniques like FTIR, UV¡VVisible, 1 H-NMR, fluorescence emission, SEM, DSC, TGA and GPC. The Fur grafted PECH was subjected to drug release study at three different pHs from which the drug release model and mechanism were determined. The structurally modified PECH exhibited the SO 2 stretching at 1121?cm ?1 . The 1 H-NMR spectrum confirmed the chemical grafting of Fur onto PECH backbone. After the chemical grafting reaction, the M w of PECH was increased to 73,216?g/mol. The drug release under acid pH followed the super case transportation mechanism. Graphical abstract: [Figure not available: see fulltext.]. ? 2018, Institute of Chemistry, Slovak Academy of Sciences.
Subjects
1 H-NMR characterization
Drug release study
GPC study
Structural modification
SDGs
Type
journal article