Immunogenicity and Safety of Standard-Titer Aik-C Measles Vaccine in 9- Month-Old Infants
Resource
VIRAL IMMUNOLOGY v.12 n.4 pp.343-348
Journal
VIRAL IMMUNOLOGY
Journal Volume
v.12
Journal Issue
n.4
Pages
343-348
Date Issued
1999
Date
1999
Author(s)
HUANG, LI-MIN
CHEN, CHUNG-MING
TSAI, CHANG-HAI
LEE, CHIN-YUN
Abstract
Because of the interference by maternal antibody before 1 year of age, the Schwarz strain of measles vaccine, which has been routinely used in Taiwan, must be given at 9 months and 15 months of age to ensure an optimal immune response. The AIK-C strain of measles vaccine has been reported to be highly immunogenic. This study evaluated the immunogenicity and safety of the AIK-C vaccine in 9-month-old Taiwanese infants. A total of 135 infants were recruited and were randomly assigned to receive either Schwarz vaccine (68 cases) or AIK-C vaccine (67 cases). Measles antibodies were assayed before and 1 month after the vaccination. Sixty- five (97%) infants who received the AIK-C vaccine seroconverted after the vaccination, whereas the seroconversion rate in those receiving the Schwarz vaccine was 77% (P = 0.001). The incidences of adverse reactions were comparable between the two groups. We conclude that even in 1990s, the failure rate of Schwarz vaccine in 9-month-old infants is still high . The AIK-C vaccine is more immunogenic in infants and its long-term immunogenicity and safety deserve further evaluation.
Subjects
Antibodies,Viral
Comparative Study
Female
Measles Vaccine
Measles virus
Vaccination
SDGs
Type
journal article