Ureteral obstruction caused by L-asparaginase induced pancreatitis in a child with acute lymphoblastic leukemia
Journal
Journal of the Formosan Medical Association
Journal Volume
103
Journal Issue
5
Pages
380-384
Date Issued
2004
Author(s)
Abstract
I-asparaginase, an effective antileukemia and antilymphoma agent, is toxic to many organ systems. We report a case of ureteral obstruction caused by L-asparaginase via the inflammatory complication of acute pancreatitis. The patient was an 11-year-old boy with acute lymphoblastic leukemia. Six days after completing a 4-week induction therapy containing 9 doses of L-asparaginase, severe left abdominal pain developed. Abdominal computed tomography showed phlegmon formation anterior to the pancreatic head and in the left posterior pararenal space. The strands of inflammatory soft tissues encased the upper third of the left ureter, causing left hydroureter and left hydronephrosis. The ureteral obstruction resolved after insertion of a double-J catheter that remained in place for 66 days. This case suggest that L-asparaginase may play a role in the pathogenesis of ureteral obstruction in children receiving chemotherapy.
SDGs
Other Subjects
asparaginase; cytarabine; flavoxate; fresh frozen plasma; hydrocortisone; idarubicin; methotrexate; netilmicin; prednisolone; spasmolytic agent; timentin; vincristine; antineoplastic agent; asparaginase; abdominal pain; abdominal radiography; acute lymphoblastic leukemia; acute pancreatitis; article; case report; childhood leukemia; clinical feature; computer assisted tomography; disease severity; human; hydronephrosis; hydroureter; male; outcomes research; pathogenesis; percutaneous nephrostomy; phlegmon; school child; soft tissue; ureter catheterization; ureter obstruction; acute disease; acute lymphocytic leukemia; chemically induced disorder; child; pancreatitis; pathology; review; ureter obstruction; vein thrombosis; Acute Disease; Antineoplastic Agents; Asparaginase; Child; Humans; Leukemia, Lymphocytic, Acute; Male; Pancreatitis; Ureteral Obstruction; Venous Thrombosis
Type
journal article