Rabies Virus Glycoprotein-Mediated Transportation and T Cell Infiltration to Brain Tumor by Magnetoelectric Gold Yarnballs
Journal
ACS Nano
Journal Volume
16
Journal Issue
3
Start Page
4014
End Page
4027
ISSN
19360851
Date Issued
2022
Author(s)
Cheng, Wei
Su, Yu-Lin
Hsu, Hao-Hsiang
Lin, Ya-Hui
Huang, Wei-Chen
Lu, Yu-Jen
Chiang, Chi-Shiun
Hu, Shang-Hsiu
Abstract
T lymphocyte infiltration with immunotherapy potentially suppresses most devastating brain tumors. However, local immune privilege and tumor heterogeneity usually limit the penetration of immune cells and therapeutic agents into brain tumors, leading to tumor recurrence after treatment. Here, a rabies virus glycoprotein (RVG)-camouflaged gold yarnball (RVG@GY) that can boost the targeting efficiency at a brain tumor via dual hierarchy- and RVG-mediated spinal cord transportation, facilitating the decrease of tumor heterogeneity for T cell infiltration, is developed. Upon magnetoelectric irradiation, the electron current generated on the GYs activates the electrolytic penetration of palbociclib-loaded dendrimer (Den[Pb]) deep into tumors. In addition, the high-density GYs at brain tumors also induces the disruption of cell-cell interactions and T cell infiltration. The integration of the electrolytic effects and T cell infiltration promoted by drug-loaded RVG@GYs deep in the brain tumor elicits sufficient T cell numbers and effectively prolongs the survival rate of mice with orthotopic brain tumors. © 2022 American Chemical Society. All rights reserved.
Subjects
drug delivery
immune therapy
nanoparticles
rabies virus glycoprotein
T cell infiltration
Publisher
American Chemical Society
Type
journal article