Molecular Characterization of a Newly Identified Rat Parvovirus in Taiwan
Date Issued
2009
Date
2009
Author(s)
Liao, Yi-Chun
Abstract
Rodent parvoviruses are one of the most prevalent infectious agents in the laboratory rodent and have been documented to interfere with in vivo and in vitro research. A newly recognized rat parvovirus (RPV) distinct from the prototypic RPV was recently identified in naturally infected laboratory rats in Taiwan. In present study, the viral DNA sequence and the predicted amino acid sequences of the new variant of RPV were determined and compared to RPV-1a, RPV-1b, RPV/UT and other rodent parvoviruses. DNA sequence fragment a total of 4759 nucleotides in length, encompassing two large and several small open reading frames (ORFs) were determined. Nucleotide and amino acid sequence comparisons showed that the variant of RPV is most closely related to RPV-1a and RPV-1b and distinctly different from RPV/UT and other rodent parvoviruses. The virus was designated rat parvovirus type 1c (RPV-1c). The phylogenetic analyses reveal that RPV-1c is a variant of RPV-1 group, including RPV-1a and RPV-1b. RPV-1c is the first molecularly characterized RPV variant identified outside of USA.
Subjects
rodent parvoviruses
rat parvovirus type 1c
Type
thesis
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