第二型血管張力素受器對皮質醛酮分泌和腎上腺細胞自毀的影響以及機制之探討(1/2)
Date Issued
2003
Date
2003
Author(s)
吳寬墩
DOI
912314B002340
Abstract
Angiotensin II is an important hormone of renin-angiotensin-aldosterone system
(RAA system). Many types of Angiotensin II receptors has been found, in which, type I is best known due to its relationship to hypertension. In previous studies, we have
known that there are several different physiological functions between ATR1 and
ATR2. The general functions of ATR2 are: inhibition of and cell growth, stimulate
cell apoptosis or differentiation, regenerate neural cell, inhibit angiogenesis, stabilize
blood pressure, emotion and antagonizes ATR1 physiologically. We take H295R cell,
a cell line derived from human adrenocortical carcinoma which was documented to
have no ATR2 by RT-PCR. So we set up a model of ATR2 transfected H295 cell to
explore the roles of ATR2 in adrenal cortex and its signal transduction.
So far, we have transfected ATR2 into H295R cell, and get stable cell line. Then,
we treat ATR2-H295R cell with angiotensin II. The initial result is that aldosterone
production decrease after ATR2 transfection, but we need further experiment to
confirm this.
Subjects
Angiotension II receptor type 2
aldosterone
human adrenocortical
carcinoma cell-H295R cell
carcinoma cell-H295R cell
transfection
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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