Family history of cancer and head and neck cancer risk in a Chinese population
Journal
Asian Pacific Journal of Cancer Prevention
Journal Volume
16
Journal Issue
17
Pages
8003-8008
Date Issued
2015
Author(s)
Huang Y.-H.J
Lee Y.-C.A
Li Q
Chen C.-J
Hsu W.-L
Zhu C
Pan J
Shen H
Ma H
Cai L
He B
Wang Y
Zhou X
Ji Q
Zhou B
Wu W
Ma J
Boffetta P
Zhang Z.-F
Dai M
Hashibe M.
Abstract
Background: The aim of this study was to investigate whether family history of cancer is associated with head and neck cancer risk in a Chinese population. Materials and Methods: This case-control study included 921 cases and 806 controls. Recruitment was from December 2010 to January 2015 in eight centers in East Asia. Controls were matched to cases with reference to sex, 5-year age group, ethnicity, and residence area at each of the centers. Results: We observed an increased risk of head and neck cancer due to first degree family history of head and neck cancer, but after adjustment for tobacco smoking, alcohol drinking and betel quid chewing the association was no longer apparent. The adjusted OR were 1.10 (95% CI=0.80-1.50) for family history of tobacco-related cancer and 0.96 (95%CI=0.75-1.24) for family history of any cancer with adjustment for tobacco, betel quid and alcohol habits. The ORs for having a first-degree relative with HNC were higher in all tobacco/ alcohol subgroups. Conclusions: We did not observe a strong association between family history of head and neck cancer and head and neck cancer risk after taking into account lifestyle factors. Our study suggests that an increased risk due to family history of head and neck cancer may be due to shared risk factors. Further studies may be needed to assess the lifestyle factors of the relatives.
Subjects
Family history of cancer; Head and neck cancer
SDGs
Other Subjects
Areca; Asian continental ancestry group; case control study; China; drinking behavior; family; female; Head and Neck Neoplasms; human; lifestyle; male; middle aged; risk factor; smoking; Alcohol Drinking; Areca; Asian Continental Ancestry Group; Case-Control Studies; China; Family; Female; Head and Neck Neoplasms; Humans; Life Style; Male; Middle Aged; Risk Factors; Smoking
Publisher
Asian Pacific Organization for Cancer Prevention
Type
journal article