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  4. Correlation between Stratus OCT and GDx VCC in early glaucoma, ocular hypertension and glaucoma suspect eyes
 
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Correlation between Stratus OCT and GDx VCC in early glaucoma, ocular hypertension and glaucoma suspect eyes

Journal
Journal of Optometry
Journal Volume
5
Journal Issue
1
Pages
24-30
Date Issued
2012
Author(s)
Chen H.-Y.
Huang M.-L.
I-JONG WANG  
Chen W.-C.
DOI
10.1016/j.optom.2012.01.001
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862805819&doi=10.1016%2fj.optom.2012.01.001&partnerID=40&md5=078ff0df6cdef473419ae11c20dc516d
https://scholars.lib.ntu.edu.tw/handle/123456789/567291
Abstract
To study the correlation between Stratus optical coherence tomography (OCT) and scanning laser polarimetry (GDx VCC) in measuring retinal nerve fiber layer (RNFL) thickness in eyes with early glaucoma (EG), ocular hypertension (OH), and glaucoma suspect (GS) in a Taiwan Chinese population. One eye each of 170 subjects (50 eyes with EG, 32 eyes with OH, 38 eyes with GS and 50 healthy eyes) was included. The RNFL thickness was measured by both technologies and three parameters (average, superior and inferior thickness) were correlated using the Pearson's correlation coefficient (r) in each group. Diagnostic capability of two instruments was evaluated in EG, OH and GS eyes based on the area under the receive operator characteristic (AROC) curve. In healthy and EG eyes, three RNFL parameters were significantly correlated. In OH eye, there was no significant correlation in three parameters. In GS eye, there was significant correlation in inferior thickness only. For healthy vs EG eye, the best parameter with largest AROC was nerve fiber indicator (0.798) for GDx VCC and average thickness (0.787) for OCT. The diagnostic capability of two techniques is poor in OH (AROC, 0.510–0.645) and GS eyes (AROC, 0.510–0.689). The RNFL thickness measured by OCT and GDx VCC was well correlated in EG and healthy eyes but poorly correlated in OH and GS eyes. When managing the case with OH or GS eye, we should be cautious in interpreting different imaging data. Estudiar la correlación entre la tomografía de coherencia óptica (OCT) Stratus y la polarimetría láser de barrido (GDx VCC) en la medición del espesor de la capa de fibras nerviosas de la retina (CFNR) en ojos con glaucoma temprano (GT), hipertensión ocular (HO) y sospecha de glaucoma (SG) en una población de chinos taiwaneses. Se incluyeron 170 sujetos, un ojo de cada uno de ellos (50 ojos con GT, 32 ojos con HO, 38 ojos con SG y 50 ojos sanos). Se midió el espesor de la CFNR con ambas técnicas y se correlacionaron tres parámetros (espesor medio, superior e inferior) utilizando el coeficiente de correlación de Pearson (r) en cada grupo. Se evaluó la capacidad de diagnóstico de ambos instrumentos en ojos con GT, HO y SG basándose en el área bajo la curva de la característica operativa del receptor (AROC). En ojos sanos y con GT, se correlacionaron de manera significativa tres parámetros de CFNR. En los ojos con HO, no hubo correlación significativa en tres parámetros. En ojos con SG, hubo correlación significativa únicamente en el espesor inferior. Para ojos sanos frente a GT, el mejor parámetro con la mayor AROC fue el indicador de fibras nerviosas (0,798) en GDx VCC y el espesor medio (0,787) en OCT. La capacidad de diagnóstico de ambas técnicas es baja para ojos con HO (AROC: 0,510–0,645) y SG (AROC: 0,510–0,689). El espesor de la CFNR medido por OCT y GDx VCC presentó una buena correlación en ojos con GT y sanos, pero muy baja en ojos con HO y SG. A la hora de tratar casos de ojos con HO o SG, deberemos ser prudentes al interpretar los diferentes datos de exploraciones por imagen.
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Type
journal article

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