Regulating epithelial-mesenchymal plasticity from 3D genome organization.
Journal
Communications biology
Journal Volume
7
Journal Issue
1
Start Page
Article number 750
ISSN
2399-3642
Date Issued
2024-12
Author(s)
Abstract
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression. As our understanding evolves, it is clear the reversible execution of EMT arises from complex epigenomic regulation involving histone modifications and 3-dimensional (3D) genome structural changes, leading to a cascade of transcriptional events. This review summarizes current knowledge on chromatin organization in EMT, with a focus on hierarchical structures of the 3D genome and chromatin accessibility changes.
Type
other