Rapid dose-dependent effect of clozapine on a schizophrenic patient's lipid profile
Journal
Journal of Psychopharmacology
Journal Volume
23
Journal Issue
4
Pages
465-467
Date Issued
2009
Author(s)
Abstract
Clozapine is known to be associated with higher risk of metabolic syndrome, including dyslipidaemia, but the mechanisms of such a relationship are still under debate. The case we reported shows a seemingly dose-dependent effect of clozapine on a patientgs lipid profiles with no influence on his blood sugar in a relatively short period of time. A direct effect of clozapine on lipid metabolism, independent of insulin or obesity-related metabolic changes, is suggested. The rapid effect of clozapine on lipid profile allows fine-tuning in dose adjustment while treating refractory schizophrenia complicated with drug-related dyslipidaemia but worrying about psychotic rebound during clozapine discontinuation. ? 2009 British Association for Psychopharmacology.
SDGs
Other Subjects
cholesterol; clozapine; ezetimibe; fenofibrate; fluphenazine; fluphenazine decanoate; glucose; haloperidol; triacylglycerol; trifluoperazine; zotepine; zuclopenthixol; adult; article; case report; cholesterol blood level; clinical feature; delusion; dose response; drug dose reduction; drug dose titration; drug effect; dyslipidemia; hallucination; human; irritability; lipid metabolism; male; priority journal; schizophrenia; symptom; triacylglycerol blood level; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Dyslipidemias; Humans; Male; Middle Aged; Schizophrenia; Time Factors
Type
journal article