Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways
Journal
Frontiers in Endocrinology
Journal Volume
11
Pages
607968
Date Issued
2021
Author(s)
Abstract
suppression of the RhoA/ROCK/ERK and p38 MAPK signaling pathways. Thus, our study provides evidence that simvastatin and ROCK inhibitors may be potential therapeutic drugs for the prevention and treatment of orbital fibrosis in GO.
SDGs
Publisher
Frontiers Media S.A.
Type
journal article