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Studies on the Enhancement of Cellular Immunity Using Mushroom β- Glucan
Date Issued
2008
Date
2008
Author(s)
Wen, Shih-Ya
Abstract
Mushroom has a long history of use in folk medicine. It has been report that mushroom contains various biologically active compounds, especially, such as beta-glucan. In the present study, C57BL/6 mice were orally administered mushroom beta-glucan, and antitumor immunity was examined.he result revealed higher level of NK cell-mediated cytotoxicity after treating with beta-glucan for 14 days in tumor-unbearing mice. The inhibition of tumor growth in Lewis lung carcinoma (LLC)-bearing mice treated with beta-glucan has been observed. Oral administration of mushroom beta-glucan in different concentrations significantly reduced the tumor weight in a dose-dependent manner, with an inhibition more than 70%. It also shows the treatment of the highest concentration of glucan elevated the cytotoxicity of natural killer cell and the mitogen-induced lymphoproliferative activity of spleen cells. In pre- and simultaneous treatment, the inhibition of tumor growth are higher than control group. After pre-treatment of glucan, the proliferation of lymphocytes is significantly increased. n conclusion, the beta-glucan derived from the mushroom could be used as immunomodulator and anti tumor agent in mice.
Subjects
glucan
NK
tumor
immunity
mushroom
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Name
ntu-97-R95b45007-1.pdf
Size
23.32 KB
Format
Adobe PDF
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