Streptococcus pneumoniae resistance to penicillin and other β-lactam antibiotics from isolates at a University hospital in Taiwan
Journal
Journal of Infection and Chemotherapy
Journal Volume
3
Journal Issue
2
Pages
103-106
Date Issued
1997
Author(s)
Abstract
The in vitro susceptibility to 9 β-lactam antibiotics of 65 clinical strains of Streptococcus pneumoniae collected from a teaching hospital in Taiwan during the period from 1989 to 1994 were studied. Minimum inhibitory concentrations (MIC) were determined by the agar dilution method with 5% horse blood. Intermediate resistance to penicillin G was found in 24.6% of the strains (MIC, 0.125 to 1 μg/mL) and 7.7% of the strains were fully-resistant to penicillin G (MIC, ≥ 2 μg/mL). Ten strains (15.4%) were fully-resistant to cefotaxime (MIC, ≥ 2 μg/mL), whereas 3 strains (4.6%) showed intermediate resistance (MIC 1 μg/mL). The intermediate- and fully-resistant rates for penicillin increased from 12.5% and 0% in the period 1989 to 1991 to 27.3% and 22.7% in 1994, respectively. The rate of strains intermediately- and fully-resistant to cefotaxime increased from 0% in the period 1989 to 1991 to 9.1 % and 22.7%, in 1994, respectively. There was also a high probability of resistance to cefotaxime in strains that were intermediately- or fully-resistant to penicillin G. © JSC/CLJ 1997.
SDGs
Publisher
Springer Japan
Type
journal article