Studies on the chemical constituents of the fruit of Cnidium monnieri (L.) Cusson and the root of Paeonia lactiflora Pall.
Date Issued
2006
Date
2006
Author(s)
Hu, Wan-Chiao
DOI
zh-TW
Abstract
Cnidium monnier is a herb annual. Cnidium monnieri (L.) Cusson is dried ripe fruits of Cnidium monnieri has been used in classical traditional Chinese medicine for several diseases. They distributes over Taiwan and mainland China.
The methanol extract from the Cnidium monnieri (L.) Cusson was concentrated to give residue which was partitioned between ethyl acetate and water. The ethyl acetate layer was separated by column chromatography on silica gel, preparative thin layer chromatography and HPLC to afford forty-four compounds. Of these compounds, eight compounds are new and two compound are isolated for the first time from natural sources. The total isolated included thirty-four courmarins, eight chromones, and two aromatic compounds.
Paeonia lactiflora Pall. is a herb pereannial. Its dried roots has several medicinal applications in classical traditional Chinese medicine for supplies blood, controls pain, alleviates sudden onset of disease, subdues hyperactive liver, controls excessive sweating. They distributes over Taiwan and mainland China.
The methanol extract from the roots of Paeonia lactiflora Pall. was concentrated to give residue which was partitioned between ethyl acetate and water. The ethyl acetate layer was separated by column chromatography on silica gel, preparative thin layer chromatography, and HPLC to afford thirteen compounds. One of these compounds is isolated for the first time from natural sources. The total isolated included eight aromatic compounds, one steroid, one triterpenoid, one flavonoid, and two others were evaluated with telomerase inhibition.
The structure of known compounds were elucidated by comparison of their spectral data with related literature values. The structure of new compounds were identified by spectroscopic methods including 1D and 2D NMR.
Subjects
蛇床子
芍片
Cnidium monnieri (L.) Cusson
Paeonia lactiflora Pall.
Type
thesis
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