Eunicellin-based diterpenoids from the formosan soft coral klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils
Journal
Journal of Natural Products
Journal Volume
76
Journal Issue
9
Pages
1661-1667
Date Issued
2013
Author(s)
Abstract
Eleven new eunicellin-based diterpenoids possessing a cladiellane skeleton with a C-2, C-9 ether bridge, klymollins I-S (1-11), have been isolated from the EtOAc extract of the soft coral Klyxum molle from Taiwan waters. The structures of compounds 1-11 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). Compound 5 exhibited cytotoxicity toward several cancer cell lines. Compound 5 is the first eunicellin-based metabolite bearing a phenyl group and displays significant inhibition of both superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. ? 2013 The American Chemical Society and American Society of Pharmacognosy.
SDGs
Other Subjects
cytochalasin B; diterpenoid; elastase; formylmethionylleucylphenylalanine; klymollins i; klymollins j; klymollins k; klymollins l; klymollins m; klymollins n; klymollins o; klymollins p; klymollins q; klymollins r; klymollins s; superoxide; unclassified drug; article; cancer cell culture; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug activity; drug isolation; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; human; human cell; IC 50; Klyxum molle; neutrophil; nuclear Overhauser effect; proton nuclear magnetic resonance; structure activity relation; Taiwan; Animals; Anthozoa; Antineoplastic Agents; Cytochalasin B; Diterpenes; Drug Screening Assays, Antitumor; Humans; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Elastase; Superoxides; Taiwan
Type
journal article