Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding
Journal
Journal of the Chinese Chemical Society
Journal Volume
50
Journal Issue
3 A
Pages
335-338
Date Issued
2003
Author(s)
Abstract
Abstract The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding‐unfolding. Thermodynamics and kinetics of protein folding‐unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35 , 5538 (1996).) and several characteristic properties are deduced using our theoretical model.
Type
journal article