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  3. Epidemiology and Preventive Medicine / 流行病學與預防醫學研究所
  4. Primary hypercholesterolemia, carotid atherosclerosis and insulin resistance among Chinese
 
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Primary hypercholesterolemia, carotid atherosclerosis and insulin resistance among Chinese

Journal
Lipids
Journal Volume
43
Journal Issue
2
Pages
117-124
Date Issued
2008-02
Author(s)
KUO-LIONG CHIEN  
Liau, Chiau-Suong
MING-FONG CHEN  
Lee, Yuan-Teh
JIANN-SHING JENG  
Hwang B.-S.
TA-CHEN SU  
DOI
10.1007/s11745-007-3138-1
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-42549149860&doi=10.1007%2fs11745-007-3138-1&partnerID=40&md5=6a47fea28a81dcae7e053304e73498be
https://scholars.lib.ntu.edu.tw/handle/123456789/608989
Abstract
We investigated the genetic contributions to carotid atherosclerosis and insulin resistance in Chinese patients with primary hypercholesterolemia. A family study of probands from the outpatient clinics in patients with high low-density-lipoprotein cholesterol levels was conducted. A total of 62 families (360 subjects) underwent carotid ultrasonography and insulin resistance measurement. The correlation coefficients of carotid intima-media thickness (IMT) were high among spouse, parent-offspring, and sibling pairs (0.39, 0.38 and 0.35, respectively). All insulin indices and IMT had significant estimates of heritability, of which fasting insulin had the highest heritability (0.410 ± 0.104, P = 0.0001), followed by homeostasis model assessment (HOMA) (0.395 ± 0.108, P = 0.0001). The estimated heritability of IMT was significant (0.185 ± 0.103, P = 0.025) but not of plaque score. Bivariate genetic coefficient between IMT and HOMA was 0.569 ± 0.292, while the environmental coefficient was 0.028 ± 0.103. The study confirms a relationship between insulin resistance and atherosclerosis and, in particular, between insulin resistance and the thickening of the arterial wall. Moreover, it shows that genetics influence both insulin resistance and atherosclerosis, implying that the management of insulin resistance may benefit the prevention of atherosclerotic disease in familial hypercholesterolemia. © 2007 AOCS.
Subjects
Carotid atherosclerosis; Family study; Hypercholesterolemia; Insulin resistance
Type
journal article

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