Intravasation-Related Metastatic Factors in Colorectal Cancer
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
Tien, Yu-Wen
DOI
922311B002099
Abstract
Alterations in adhesion molecules, angiogenesis, and matrix metalloproteinases
have been associated with metastasis and intravasation. The present study
investigated the role of these metastatic factors in the context of primary colorectal
tumor. Intravasated colorectal epithelial cells were detected by an RT-PCR assay, and
expression of E-cadherin, α-catenin, or β-catenin as well as the vascularity of
tumor was assessed by immunohistochemical staining. Activity of matrix
metalloproteinase was assessed by gelatin zymography. The tumor venous blood was
positive for GCC mRNA expression in 40 of 68 patients, but alteration in expression
of E-cadherin, α-catenin, or β-catenin was not significantly associated with the
presence of colorectal epithelial cells in paired portal venous blood. Further, matrix
metalloproteinase activity did not correlate with the presence of intravasated
colorectal epithelial cells. Multivariate analysis demonstrated that the only factor
associated with intravasated colorectal tumor cells was vascularity of the tumor. Thus,
metastasis of colon cancer may result from passive entry into the circulation
secondary to angiogenic factors and does not appear to involve other metastatic
factors studied in our experiments.
Subjects
Matrix metalloproteinase
E-cadherin
α-catenin
β-catenin
metastasis
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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