Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection
Journal
Clinical Microbiology and Infection
Journal Volume
21
Journal Issue
2
Pages
197-203
Date Issued
2015
Author(s)
Song L.-W.
Liu P.-G
Zhang T.-Y
Cheng X.-D
Wu H.-L
Hao X.-K
Yuan Q
Zhang J
Xia N.-S.
Abstract
We previously demonstrated that pretreatment quantitative anti-hepatitis B core protein (qAnti-HBc) levels can predict the treatment response for both interferon and nucleoside analogue therapy, but the characteristics of qAnti-HBc during chronic hepatitis B virus (HBV) infection remain poorly understood. To understand this issue, the qAnti-HBc levels were evaluated in individuals with past HBV infection, occult HBV infection and chronic HBV infection in the immune tolerance phase, immune clearance phase, low-replicative phase and hepatitis B e antigen (HBeAg)-negative hepatitis phase. Individuals with hepatitis B surface antigen (n=598, 3.74±0.90 log10 IU/mL) had significantly higher (p<0.001, approximately 1000-fold) serum qAnti-HBc levels than those who had occult HBV, and serum qAnti-HBc levels were significantly higher in the occult HBV group than in the past HBV infection group (p<0.001). qAnti-HBc levels were positively correlated with alanine aminotransferase levels (R=0.663, p<0.001), and subjects with an abnormal alanine aminotransferase level had a higher qAnti-HBc level (p<0.001). Serum qAnti-HBc level varied in different phases of HBV infection, as determined by host immune status. Serum qAnti-HBc level is strongly associated with hepatitis activity in subjects with chronic HBV infection. ? 2014 European Society of Clinical Microbiology and Infectious Diseases.
SDGs
Other Subjects
alanine aminotransferase; hepatitis B core antibody; hepatitis B surface antigen; hepatitis B(e) antigen; alanine aminotransferase; hepatitis B antibody; hepatitis B core antigen; adult; Article; blood donor; female; hepatitis B; Hepatitis B virus; human; immune status; immunological tolerance; liver cirrhosis; major clinical study; male; nonhuman; priority journal; quantitative analysis; virus load; virus replication; adolescent; aged; blood; child; chronic hepatitis B; cohort analysis; cross-sectional study; immunology; infant; middle aged; pathology; preschool child; very elderly; young adult; Hepatitis B virus; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Child; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Female; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B, Chronic; Humans; Infant; Male; Middle Aged; Young Adult
Publisher
Elsevier
Type
journal article