Can Symptoms Predict Delayed Gastric Emptying in Diabetic Patients: A Multicenter Study to Revisit Gastroparesis.
Journal
Journal of Neurogastroenterology and Motility
Journal Volume
31
Journal Issue
4
Start Page
438 - 446
ISSN
2093-0879
Date Issued
2025-10-30
Author(s)
Chung, Chen-Shuan
Hung, Jui-Sheng
Hsu, Ming-Hung
Chin, Ning-Hsuan
Wong, Ming-Wun
Lei, Wei-Yi
Lee, Tzong-His
Chen, Hua-Fen
Wu, Jiann-Ming
Chen, Kuo-Hsin
Wang, Wen-Lun
Chen, Chien-Lin
Abstract
Background/Aims This study aims to assess whether specific symptoms from the Gastroparesis Cardinal Symptom Index (GCSI) could predict delayed gastric emptying and to establish the prevalence of gastroparesis (GP). Methods Diabetic patients were recruited from a multicenter cross-sectional cohort. Each participant underwent esophagogastroduodenoscopy, symptom assessment by GCSI, and solid-meal gastric emptying scintigraphy (GES). GP was defined by GES data showing a T1/2 > 85 minutes and/or gastric retention > 8% at 3 hours. Results Among 138 patients, those with delayed GES (21.01%) had a higher incidence of nephropathy (51.72% vs 22.02%, P = 0.002) and lower albumin levels (3.91 g/dL vs 4.18 g/dL, P = 0.003). Cardinal symptoms such as nausea (P = 0.011), retching (P = 0.040), vomiting (P = 0.010), stomach fullness (P = 0.001), fullness after eating (P = 0.025), and loss of appetite (P = 0.039) were more prevalent in patients with abnormal GES. A higher overall GCSI score was found to independently predict delayed gastric emptying (P = 0.028) in multivariate analysis. The area under the receiver operating characteristic curve for the GCSI in predicting GP was 0.672, with an optimal cutoff value of 1.78 (sensitivity 79.31%, specificity 49.54%). The prevalence of GP, defined by both GCSI ≥ 1.78 and abnormal GES, was 16.67% among diabetic patients. Notably, 16 (11.59%) patients had rapid emptying. Conclusion Diabetic patients exhibiting specific cardinal symptoms should be considered for GES evaluation, as the overall GCSI score independently predicts delayed gastric emptying. This study suggests that the GCSI may be useful as a screening tool rather than a diagnostic method for diabetic gastroparesis.
Subjects
Diabetes
Gastric emptying scintigraphy
Gastroparesis
Gastroparesis Cardinal Symptoms Index
Nephropathy
Publisher
Korean Society of Neurogastroenterology and Motility
Type
journal article