The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics
Journal
Physiological Measurement
Journal Volume
29
Journal Issue
9
Pages
1055-1069
Date Issued
2008
Author(s)
Peng T.
Ainslie P.N.
Cotter J.D.
Murrell C.
Thomas K.
Williams M.J.A.
George K.
Shave R.
Rowley A.B.
Payne S.J.
Abstract
Although the effects of ageing on cardiovascular control and particularly the response to orthostatic stress have been the subject of many studies, the interaction between the cardiovascular and cerebral regulation mechanisms is still not fully understood. Wavelet cross-correlation is used here to assess the coupling and synchronization between low-frequency oscillations (LFOs) observed in cerebral hemodynamics, as measured using cerebral blood flow velocity (CBFV) and cerebral oxygenation (O2Hb), and systemic cardiovascular dynamics, as measured using heart rate (HR) and arterial blood pressure (ABP), in both old and young healthy subjects undergoing head-up tilt table testing. Statistically significant increases in correlation values are found in the interaction of cerebral and cardiovascular LFOs for young subjects (P < 0.01 for HR-ABP, P < 0.001 for HR-O2Hb and ABP-O2Hb), but not in old subjects under orthostatic stress. The coupling between the cerebrovascular and wider cardiovascular systems in response to orthostatic stress thus appears to be impaired with ageing. ? 2008 Institute of Physics and Engineering in Medicine.
Subjects
Blood pressure
Blood vessels
Flow velocity
Hemodynamics
Infrared devices
Arterial blood pressure
Autonomic control
Cardiovascular control
Cardiovascular dynamics
Effect of ageing
Frequency oscillations
Heart-rate
Lower frequencies
Orthostatic stress
Tilt-testing
Near infrared spectroscopy
hemoglobin
adult
aged
aging
arterial pressure
article
blood flow velocity
body posture
brain blood flow
brain circulation
controlled study
correlation coefficient
head tilting
heart rate
hemodynamics
human
human experiment
near infrared spectroscopy
normal human
orthostatic stress
oscillation
oxygenation
priority journal
spectroscopy
tissue oxygenation
SDGs
Type
journal article