Technical developments on clinical diffusion tensor imaging and neural tractography (1/2)
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
DOI
932314B002143
Abstract
The specific aim for the first fiscal year
of this project is to test our hypothesis that
the FLAIR technique helps to improve DTI
white matter tractography by eliminating
CSF partial volume effects. Seven healthy
young adults aged 23-37 underwent both
conventional and FLAIR DTI on a 1.5 Tesla
system. Each subject was scanned five
times. Tractography was performed with
both sequences using two algorithms: One
voxel-based method (EZ-tracing) with global
seed points, and the other based on subvoxel
tractography (tensor deflection) using manual
encircling of local seed points. Total
volume of the fibers tracked was compared
for the two types of images. Fiber tracking
was found to be substantially more successful
in FLAIR DTI near the lateral ventricles and
the sulci where CSF partial volume effects
are likely to be present. Minor false tracts
on FLAIR images possibly due to reduced
SNR were found in regions relatively free
from CSF contamination, but did not affect
tracking of major peri-ventricular white
matter bundles such as those related to the
corpus callosum or the corona radiata.
Excluding false tracts, the FLAIR technique
detected an average of 17% more fibers in
volume than with conventional DTI in the
peri-ventricular regions (p < 0.0005). It is
concluded that despite of reduced SNR and
longer scan time, FLAIR is an effective
means that helps to improve tractography.
Subjects
Diffusion tensor imaging
white
matter tractography
matter tractography
partial volume
effects
effects
fluid-attenuated inversion
recovery
recovery
CSF suppression
Publisher
臺北市：國立臺灣大學電機工程學系暨研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
932314B002143.pdf
Size
135.05 KB
Format
Adobe PDF
Checksum
(MD5):1a18ed3eff8e0780e906e8c27d65bd01