Highly-efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex-catalyzed coupling of acyl chlorides and terminal alkynes for the formation of ynones
Journal
Tetrahedron
Journal Volume
65
Journal Issue
49
Pages
10134-10141
Date Issued
2009
Author(s)
Abstract
A highly-efficient and practical method for the formation of ynones from a variety of acyl chlorides and terminal alkynes catalyzed by a nanosized MCM-41 anchored palladium bipyridyl complex is described herein. Aroyl, heteroaroyl, and alkyl acyl chlorides were easily coupled with terminal alkynes, giving good to high isolated yields in the presence of a very low catalyst loading (0.002-0.1 mol % Pd) in Et3N or diisopropylethylamine at 50 °C. Furthermore, the reaction scale was up to 150 mmol for a single batch reaction, providing the potential for practically synthetic application. After centrifugation, the supported catalyst was able to be recycled and reused several times with only a slight decrease in activity. © 2009 Elsevier Ltd. All rights reserved.
SDGs
Type
journal article