行政院國家科學委員會專題研究計畫期中進度報告:罹患慢性肺疾病之早產兒的神經發展與影響因素研究(2/3)
Date Issued
2005
Date
2005
Author(s)
鄭素芳
DOI
932314B002042
Abstract
There were three purposes of this study:
(1) to use the Neonatal Neurobehavioral
Examination- Chinese version (NNE-C) to
evaluate the neurobehavioral development in
premature infants with chronic lung disease
(CLD) and premature infants without CLD
during neonatal period, (2) to use the clinical
and roentgenographic scoring systems to
assess the severity of respiratory disease in
these infants, and to examine the relation
between the severity of respiratory disease
and the neurobehavioral performance, and (3)
to use the cranial ultrasonography to assess
the neural integrity of these infants, and to
examine the relation between neural lesions
and the neurobehavioral development. This
study included 57 premature infants with
CLD and 53 premature infants without CLD.
The infants were administered the clinical
and roentgenographic scoring systems,
cranial ultrasonography and magnetic
resonance imaging, and the NNE-C during
neonatal period. The results showed that the
infants with CLD manifested comparable
NNE-C scores at PCA 36 weeks (p=0.09) but
lower NNE-C scores at PCA 39 weeks
(p<0.0001) than those without. The infants
with CLD showed higher clinical and
roentgenographic scores of respiratory
disease on day 14 and 28 compared with
those without (p<0.001). The cranial
ultrasonographic examinations revealed that
the infants with CLD had similar incidences
of neural lesions (i.e., intraventricular
hemorrhage, periventricular leukomalacia,
prolonged periventricular echogenicity and
ventriculomegaly) than those without.
Regression analysis showed that when
adjusted for CLD, the severity of respiratory
disease (R2 = 0.20-0.30, p< 0.01) and neural
lesions each had significant relations with the
NNE-C scores during neonatal period (R2 =
0.04-0.06, p< 0.05). Our results suggest that
respiratory insufficiency and neural lesions
may contribute to the neurodevelopmental
outcome during neonatal period in infants
with CLD.
Subjects
早產兒
慢性肺疾病
神經發展
影響因子
Publisher
臺北市：國立臺灣大學醫學院物理治療學系暨研究所
Type
journal article
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