Biomedical Applications of DNA-Conjugated Gold Nanoparticles
Journal
ChemBioChem
Pages
1052-1062
Date Issued
2016
Author(s)
Abstract
Gold nanoparticles (AuNPs) are useful for diagnostic and biomedical applications, mainly because of their ease in preparation and conjugation, biocompatibility, and size-dependent optical properties. However, bare AuNPs do not possess specificity for targets. AuNPs conjugated with DNA aptamers offer specificity for various analytes, such as proteins and small molecules/ions. Although DNA aptamers themselves have therapeutic and target-recognizing properties, they are susceptible to degradation in vivo. When DNA aptamers are conjugated to AuNPs, their stability and cell uptake efficiency both increase, making aptamer–AuNPs suitable for biomedical applications. Additionally, drugs can be efficiently conjugated with DNA aptamer–AuNPs to further enhance their therapeutic efficiency. This review focuses on the applications of DNA aptamer-based AuNPs in several biomedical areas, including anticoagulation, anticancer, antibacterial, and antiviral applications. ? 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Subjects
AuNPs; biomedical applications; DNA aptamers; gold nanoparticles
SDGs
Other Subjects
anticoagulant agent; antiinfective agent; antineoplastic agent; antivirus agent; aptamer; DNA; gold nanoparticle; nanoconjugate; antibacterial activity; anticoagulation; antineoplastic activity; antiviral activity; biocompatibility; biomedicine; cell transport; conjugation; gene therapy; Human immunodeficiency virus infection; in vitro study; priority journal; Review
Type
journal article