Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors
Journal
2013 NSTI Nanotechnology Conference and Expo
Journal Volume
3
Pages
415-417
Date Issued
2013
Author(s)
Lin C.-Y.
Abstract
Cancer therapy has attracted people attention for many years, especially for colorectal cancer. We have used Cetuximab (epidermal growth factor receptor inhibitor) to treat metastatic colorectal cancer, but it is no use in colorectal tumors harboring KRAS mutations. Recently, the research found that Heat shock protein 90 (HSP90) inhibitors have potential targeting KRAS mutant tumors. HSP90 is a molecular chaperone protein critical for tumor survive and growth. Here, we used amphiphilic block copolymers poly(ε-caprolactone)-graft-poly(2- (dimethylamino) ethyl mefhacrylate) (PDMAEMA-PCL) synthesized by ring-opening polymerization of E-caprolactone. For drug delivery advanced application, these amphiphilic block copolymers had pH-sensitive characterization to release drugs at tumor site. In vitro cell viability showed HSP90 inhibitors reduced obvious cell growth. These results indicated that the use of the PDMAEMA-PCL loaded HSP90 inhibitors may be a potential method in cancer therapy.
Subjects
Cancer therapy; Colorectal cancer; Drug delivery; Nanoparticles; Self-assembly
SDGs
Other Subjects
Advanced applications; Amphiphilic block copolymers; Cancer therapy; Colorectal cancer; Colorectal tumors; Epidermal growth factor receptors; Heat-shock protein 90; Molecular chaperone proteins; Block copolymers; Diseases; Drug delivery; Exhibitions; Medical nanotechnology; Nanoparticles; Oncology; Self assembly; Tumors; Nanotechnology
Type
conference paper