An unusual case of ulcerative colitis with concurrent extraintestinal manifestations of primary sclerosing cholangitis, thromboembolism, hemolytic anemia, and hemochromatosis
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
38
Journal Issue
3
Pages
224-229
Date Issued
2005
Author(s)
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of intestines associated with a large number of extraintestinal manifestations (EIMs) which significantly contribute to its morbidity and mortality. A 32-year-old man presented with ulcerative colitis (UC) accompanied by the unusual coexisting clinical manifestations of primary sclerosing cholangitis, thromboembolism, and hemolytic anemia during the disease course. The incidental finding of hemochromatosis of the liver was attributed to chronic hemolysis. The full-blown EIMs and systemic complications in this patient did not appear to be attributable to drug treatment and/or infection but might have been related to both the underlying immune-mediated mechanism and the lack of early and adequate treatment for UC and its associated complications. This case emphasizes the need for early and aggressive treatment of IBD accompanied by EIMs to avoid morbidity and mortality.
SDGs
Other Subjects
low molecular weight heparin; mesalazine; prednisolone; warfarin; adult; article; case report; clinical feature; disease course; enteritis; hemochromatosis; hemolysis; hemolytic anemia; hepatomegaly; human; infection; jaundice; lung embolism; male; primary sclerosing cholangitis; thromboembolism; ulcerative colitis; Adult; Anemia, Hemolytic; Cholangitis, Sclerosing; Colitis, Ulcerative; Hemochromatosis; Humans; Male; Thromboembolism
Type
journal article