Mutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA
Journal
BMC gastroenterology
Journal Volume
14
Pages
221
Date Issued
2014-12-31
Author(s)
Abstract
Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed.
Subjects
Gene mutation; Non-polypoid colorectal neoplasm; EGFR; LATERALLY-SPREADING TUMORS; K-RAS MUTATIONS; CHINESE POPULATION; SERRATED PATHWAY; COLON CANCERS; POOR SURVIVAL; STOOL DNA; FLAT; CARCINOMA; PREVALENCE
SDGs
Other Subjects
B Raf kinase; epidermal growth factor receptor; epidermal growth factor receptor 2; protein kinase B; B Raf kinase; KRAS protein, human; oncoprotein; phosphatidylinositol 3 kinase; PIK3CA protein, human; Ras protein; adult; aged; AKT gene; Article; BRAF gene; cancer classification; cancer staging; carcinogenesis; colorectal adenoma; controlled study; disease severity; EGFR gene; epigenetics; exon; female; gene; genetic association; HER2 gene; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; middle aged; morphology; mutational analysis; oncogene K ras; PIK3CA gene; tumor volume; adenoma; colorectal tumor; genetics; mutation; nucleotide sequence; pathology; Adenoma; Aged; Colorectal Neoplasms; DNA Mutational Analysis; Female; Humans; Male; Middle Aged; Mutation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; ras Proteins
Publisher
BIOMED CENTRAL LTD
Type
journal article