A single transcutaneous injection with Botox® for dysthyroid lid retraction
Journal
Eye
Journal Volume
18
Journal Issue
5
Pages
466-469
Date Issued
2004
Author(s)
Abstract
Purpose. To evaluate the safety and efficacy of injections with botulinum toxin type A (BTTA, Botox?), given transcutaneously, in the treatment of upper lid retraction associated with thyroid eye disease (TED). Methods. A total of 15 patients (21 eyes) with a stable (TED) condition, and a euthyroid state, were enrolled into the study. There were 12 females and three males from ages 23 to 52 years. A single injection, at the centrally superior tarsal border transcutaneously, aiming at the levator aponeurosis and M?ller muscle, was administered into each eyelid with 5-6U of Botox?. All patients were followed regularly for 4-6 months. Any complications, such as ptosis, diplopia, pain, or lid ecchymosis were recorded. Results. All patients, except one, experienced much reduction of palpebral fissure. The mean difference of MRD1 between pre- and postinjections of Botox? at the first week was -3.1 mm, and the effect remained, at least, for 2 months. There were temporary complications of ptosis in three patients and vertical diplopia in two patients, lasting 3-4 weeks. Conclusions. A single transcutaneous injection with Botox? for the treatment of thyroid lid retraction is safe and effective. Some minor complications may occur, such as ptosis and diplopia; however, it may offer an alternative and temporary method for patients with dysthyroid lid retraction, who are waiting for a staged operation of either an orbital decompression or a strabismus surgery or both. ? 2004 Nature Publishing Group All rights reserved.
Subjects
Botulinum toxin type A; Thyroid eye disease; Upper lid retraction
SDGs
Other Subjects
botulinum toxin A; adult; article; clinical article; controlled study; diplopia; disease activity; drug efficacy; drug safety; ecchymosis; endocrine ophthalmopathy; euthyroidism; eye pain; eyelid; female; follow up; human; male; palpebral fissure; ptosis; single drug dose; strabismus surgery; surgical technique; transdermal drug administration
Publisher
Royal College of Ophthalmologists
Type
journal article