Plasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis
Journal
Biomarkers in Medicine
Journal Volume
11
Journal Issue
5
Pages
431-441
Date Issued
2017
Author(s)
Bai, Yongying
Lin, Huayue
Fang, Zanxi
Luo, Qing
Fang, Yizhen
Su, Yuanhui
Hu, Qing
Duan, Hongbing
Zhang, Zhong-Ying
Abstract
AIM: To investigate whether plasma miR-19a can serve as a biomarker for esophageal squamous cell carcinoma (ESCC) diagnosis and prognosis. MATERIALS & METHODS: Plasma samples from 89 ESCC, 45 benign lesion patients and 80 healthy controls were subjected to RT-qPCR analyses for miR-19a. In addition, plasma samples from 30 patients were collected before and after surgery for the same analyses. RESULTS: Plasma miR-19a was significantly increased in ESCC patients compared with healthy controls. The sensitivity of miR-19a for early stages of ESCC was 68.09%. Combination of miR-19a and cytokeratin 19 fragment 21-1 (Cyfra21-1) further improved the sensitivity to 78.70%. Moreover, plasma miR-19a level was decreased in patients after surgery. CONCLUSION: Plasma miR-19a may serve as a potential biomarker that complements Cyfra21-1 in detecting early stages of ESCC.
SDGs
Type
journal article