Effect of particle-membrane interaction on microfiltration
Date Issued
2000-10-30
Date
2000-10-30
Author(s)
DOI
892214E002012
Abstract
Protein fouling, initiated by the
interaction between proteins and mem-branes,
is the major reason for the decline
of filtration flux in microfiltration. In this project, experiments were performed with
bovine serum albumin and track-etched
polycarbonate membranes to evaluate
how fouling affects the microfiltration
process. On basis of the measurement of
filtration flux and resistance distribution,
and the analyses of SEM and AFM, it can
be found that the fouling process is
initiated by the adsorption of BSA
aggregates near the membrane pores, and
an external cake then forms which is
composed of BSA monomers and
aggregates. The analysis suggests that the
irreversible adsorption of BSA
aggregates and the reversible adsorption
of monomers are two major mechanisms
for fouling. In the beginning of filtration,
the adsorption of BSA aggregates is the
dominant mechanism for fouling. And in
the later period of filtration, the
adsorption of BSA monomers and the
compression of the external cake are
responsible for the growth of resistance.
In addition, the effects of operation
variables, such as protein concentration,
pressure difference, and pH values, on
flux decline and resistance distribution
have also been investigated.
Subjects
microfiltration
fouling
protein
flux decline
Publisher
臺北市：國立臺灣大學化學工程學系暨研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
892214E002012.pdf
Size
1.01 MB
Format
Adobe PDF
Checksum
(MD5):451330583eef0b14de67e20931c6dd06