Density of Helicobacter Pylori May Affect the Efficacy of Eradication Therapy and Ulcer Healing in Patients with Active Duodenal Ulcers
Resource
WORLD JOURNAL OF GASTROENTEROLOGY v.9 n.7 pp.1537-1540
Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Journal Volume
v.9
Journal Issue
n.7
Pages
1537-1540
Date Issued
2003
Date
2003
Author(s)
WANG, TEH-HONG
Abstract
AIM: To evaluate the association of pre-treatment Helicobacter pylori(H. pylori) density with bacterial eradication and ulcer healing rates in patients with active duodenal ulcer. METHODS: One hundred and four consecutive duodenal ulcer outpatients with H. pylori infection ascertained by gastric histopathology and C-13-urea breath test (UBT) were enrolled in this study. H. pylori density was graded histologically according to the Sydney system ( normal, mild, moderate, and marked). In each patient, lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) were used for 1 week, then 30 mg lansoprazole once daily was continued for an additional 3 weeks. Followup endoscopy was performed at 4 weeks after completion of the therapy, and UBT was done at 4 and 8 weeks after completion of the therapy. RESULTS: The H. pylori eradication rates were 88.9 %/ 100.0 %, 94.3 %/100.0 %, and 69.7 %/85.2 %; and the ulcer healing rates were 88.9 %/100.0 %, 94.3 %/100.0 %, and 63.6 %/77.8 % (intention-to-treat/ per protocol analysis) in the mild, moderate, and marked H. pylori density groups, respectively. The association of pretreatment H. pylori density with the eradication rate and ulcer healing rate was both statistically significant (P=0. 013/0.006 and 0.002/<0.001, respectively; using results of intention-to-treat/per protocol analysis). CONCLUSION: Intragastric bacterial load may affect both the outcome of eradication treatment and ulcer healing in patients with active duodenal ulcer disease.
Subjects
UREA BREATH TEST
TRIPLE THERAPY
DOUBLE-BLIND
INFECTION
CLARITHROMYCIN
MULTICENTER
Type
journal article