行政院國家科學委員會專題研究計畫成果報告:維生素E調控弓蟲抗原誘發之細胞免疫反應
Date Issued
1999
Date
1999
Author(s)
林大盛
DOI
882313B002073
Abstract
Cell-mediated immunity (CMI) is
important in controlling Toxoplasma gondii
infection frequently through the release of
cytokines by T cells. In general, Th1
cytokines inhibit T. gondii proliferation and
Th2 cytokines promote severity of the disease.
Vitamin E (VE) is the major lipid soluble
membrane antioxidant which protects the cell
from the damage by free radicals. VE can
act as an immunomodulator which is
essential in maintaining normal
immunological activity; also, VE can
influence intracellular activity, though these
mechanisms are not clear. VE can protect
and stimulate cultured lymphocytes and this
is not simply due to decrease of membrane
lipid peroxidation. Also, VE is a Th1-
response modulator by inducing IL-2 and
IFN-g production. The production of Th1
cytokines by T cells has been known to be
affected by IL-12 from macrophages.
Current studies have shown that VE is
important for maintaining and enhancing
macrophage activity by promoting
phagocytosis and IL-1 secretion. In addition,
VE-treated macrophages enhance lymphocyte
response to mitogens. Because Th1-type
CMI is the major protective immunity against
T. gondii, and because VE promotes Th1
response in addition to its antioxidant
function on immune cells, VE should play a
significant role in the modulation of immune
response stimulated by T. gondii antigens.
However, so far no report concerning this
matter has been published. Therefore,
understanding the effects of VE on
modulation of antigen-induced CMI
(especially Th 1 response), will help develop
VE as an excellent adjuvant for
immunization.
Subjects
vitamin E
immunomodulation
cell-mediated immunity
cytokines
Toxoplasma gondii
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
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